Stockholm – 30 August 2019 – Oncopeptides AB (Nasdaq Stockholm: ONCO) announced today that new updated melflufen data from the Phase 2 pivotal OP-106 HORIZON study will be presented at at the 17th International Myeloma Workshop (IMW) meeting on September 15, Boston, Massachusetts, USA. These data are from at later data cut compared with previously presented data at EHA in June or in the abstract book for IMW.
In conjuction with the presentation the new data will be available on the company webpage under:
www.oncopeptides.com / Investors & media / Presentations / 2019 IMW
In the abstract it is reported that out of 121 patients included from the HORIZON study, 70% were at least penta-class refractory and 89% of patients were at least quad-class refractory. Patients without extra-medullary disease showed a response rate of 30% with a median duration of response of 7.5 months and in patients with EMD the response rate was 24% with a median duration of response of 3.1 months.
Comment from CEO Jakob Lindberg
“HORIZON is an all-comer trial for patients with very advanced multiple myeloma. In the abstract, we show encouraging activity in patients without EMD that predominantly are penta-class refractory with a response rate of 30% and a median response duration of 7.5 months. Furthermore, when we treat patients that predominantly are penta-class refractory and suffers from EMD, we observe a response rate of 24% with a median duration of response of 3.1 months. In the context that currently available therapies on average have showed response rates less than 10% in these patients, this is a highly encouraging result as well” said Jakob Lindberg, CEO of Oncopeptides.
For further information, please contact:
Jakob Lindberg, CEO of Oncopeptides
Telephone: +46 8 615 20 40
Rein Piir, Head of Investor Relations at Oncopeptides
Cell phone: +46 70 853 72 92
This information was submitted for publication at 08.15 CET August 30, 2019.
Melflufen is a first-in-class peptide-drug conjugate that rapidly delivers a cytotoxic payload into tumor cells. Melflufen is rapidly taken up by myeloma cells due to its high lipophilicity and is immediately cleaved by peptidases to deliver an entrapped hydrophilic alkylator payload. Peptidases play a key role in protein homeostasis and feature in cellular processes such as cell-cycle progression and programmed cell death. In vitro, melflufen is 50-fold more potent in myeloma cells than the alkylator payload itself due to the increased intracellular alkylator concentration. Melflufen displays cytotoxic activity against myeloma cell lines resistant to other treatments, including alkylators, and has also demonstrated inhibition of DNA repair induction and angiogenesis in preclinical studies.
Oncopeptides is a pharmaceutical company focused on the development of targeted therapies for difficult-to-treat hematological diseases. The company is focusing on the development of the lead product candidate melflufen, a first-in-class peptide-drug conjugate that rapidly delivers a cytotoxic payload into tumor cells. Melflufen is in development as a new treatment for the hematological cancer multiple myeloma and is currently being tested in multiple clinical trials including the pivotal Phase 2 HORIZON trial and the ongoing Phase 3 OCEAN trial. Oncopeptides’ headquarters is in Stockholm, Sweden, and the company is listed in the Mid Cap segment on Nasdaq Stockholm with the ticker ONCO.
For more information please visit www.oncopeptides.com.